EFFECT OF ADJUVANTS ON THE RECTAL ABSORPTION AND LYMPHATIC UPTAKE OF PEPLEOMYCIN IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The rectal absorption of pepleomycin sulfate (PEPS) in rats was increased significantly by the coadministration with each of diclofenac (DC), sodium 5-methoxysalicylate (5-MSA) and phenylalanine enamine of ethylacetoacetate (Enamine). 5-MSA increased the lymphatic uptake of PEPS after rectal administration while DC and Enamine did not. The mechanism behind the enhancing action of 5-MSA on the lymphatic uptake of PEPS may be due to the suppressing action of 5-MSA on the vascular permeability to PEPS. DC increased the vascular permeability to PEPS but Enamine did not affect it. Findings obtained in this study may indicate that adjuvant used acts independently at the rectal mucosal membrane and at the vascular membrane for membrane for membrane permeability to PEPS.
- 公益社団法人日本薬学会の論文
著者
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Kamada Akira
Faculty Of Pharmaceutical Sciences Osaka University:the Second Osaka Police Hospital
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Kamada Akira
Faculty Of Pharmaceutical Science Osaka University
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NISHIHATA TOSHIAKI
Faculty of Pharmaceutical Sciences, Osaka University
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YAMAZAKI MASARU
Faculty of Pharmaceutical Sciences, Osaka University
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Yasui Kiyotada
Faculty Of Pharmaceutical Sciences Osaka University
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Yamazaki Masaru
Faculty Of Pharmaceutical Sciences Osaka University:the Second Osaka Police Hospital
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Yamazaki Masaru
Faculty Of Pharmaceutical Science Osaka University
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Nishihata Toshiaki
Faculty Of Pharmaceutical Sciences Osaka University:the Second Osaka Police Hospital
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Nishihata Toshiaki
Faculty Of Pharmaceutical Science Osaka University
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