THE EFFECTS OF THE ADMINISTRATION ROUTES ON THE BILIARY EXCRETION OF ANTIBIOTICS

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of the administration routes on the biliary excretion of gentamicin and cefazolin were investigated in male white rabbits. The administration routes studied were intravenous, intramuscular injection and injection into portal vein. In both antibiotics, total excretion into bile was the highest when drug was administered by the injection into portal vein. In case of gentamicin, the bile level above MIC (against P. aeruginosa) could be obtained only by the administration into portal vein. These results indicate that the administration into portal vein is useful clinically, for the drug delivery to biliary tract, especially in drugs like aminoglycoside antibiotics which have an extremely low rate of transfer to the bile.

• 公益社団法人日本薬学会の論文

著者

• Kamada Akira

  Faculty Of Pharmaceutical Science Osaka University

• TAKASE SAWAKO

  Research Labolatory, Sawai Pharmaceutical Co., Ltd.

• Takase Sawako

  Research Labolatory Sawai Pharmaceutical Co. Ltd.

関連論文

• STUDY ON THE MECHANISM BEHIND ADJUVANT ACTION OF DIETHYLETHOXYMETHYLENE MALONATE ENHANCING THE RECTAL ABSORPTION OF CEFMETAZOLE AND LYSOZYME
• EFFECT OF PHENOTHIAZINES, DISODIUM ETHYLENEDIAMINE-TETRAACETIC ACID AND DIETHYL MALEATE ON IN VITRO RAT COLONIC TRANSPORT OF CEFMETAZOLE AND INULIN
• EFFECTS OF PHENOTHIAZINES AND N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE ON RAT COLONIC ABSORPTION OF CEFMETAZOLE
• EFFECT OF POLYACRYLIC ACID GEL ON THE RECTAL ABSORPTION OF [Asu^]-EEL CALCITONIN IN RTS
• HISTOPATHOLOGIC CHANGES IN THE RECTAL MUCOSA AFTER ADMINISTRATION OF NON-STEROIDAL ANTI-INFLAMMATORY ANALGESIC SUPPOSITORIES IN RATS
• POSSIBLE MECHANISM REGULATING BARRIER FUNCTION OF RAT INTESTINAL MUCOSA AGAINST PERMEATION OF LIPOPHOBIC COMPOUND
• ENHANCED INTESTINAL ABSORPTION OF AMINO ACIDS AND AMINO ACID-LIKE DRUG BY POSSIBLE FORMATION OF ENAMINE IN ADMINISTERED SOLUTION BY THE PRESENCE OF ETHYLACETOACETATE
• EFFECT OF ADJUVANTS ON THE RECTAL ABSORPTION AND LYMPHATIC UPTAKE OF PEPLEOMYCIN IN RATS
• THE EFFECTS OF THE ADMINISTRATION ROUTES ON THE BILIARY EXCRETION OF ANTIBIOTICS
• DEVELOPMENT AND CLINICAL INVESTIGATION OF SODIUM DICLOFENAC SUSTAINED-RELEASE SUPPOSITORIES

スポンサーリンク