STUDY ON THE MECHANISM BEHIND ADJUVANT ACTION OF DIETHYLETHOXYMETHYLENE MALONATE ENHANCING THE RECTAL ABSORPTION OF CEFMETAZOLE AND LYSOZYME
スポンサーリンク
概要
- 論文の詳細を見る
Diethylethoxymethylene malonate (DEEMM) and diethyl maleate (DEM) enhanced the rectal absorption of cefmetazole in rats when studies were carried out using in vivo, in situ rectal loop and in vitro rectal everted sac method. Since an increase of cefmetazole transport was found when concentration of nonprotein sulfhydryls in rectal tissue was decreased by the presence of either DEEMM or DEM in the study using in vitro everted sac method and the enhancement of cefmetazole absorption by the coadministration of either DEEMM or DEM was suppressed by the treatment with dimercaprol, membrane permeability of rectal tissue seems to be regulated by the concentration of nonprotein sulfhydryls in rectal tissue. On the other hand, it was also found that there were differences between the action of DEEMM and the action of DEM from the following two results : 1) enhancing action of DEEMM was suppressed by the presence of calcium ion in microenema while action of DEM was not so much influenced, and 2) DEEMM enhanced the rectal absorption of lysozyme in rabbits but DEM did not.
- 公益社団法人日本薬学会の論文
著者
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Kamada Akira
Faculty Of Pharmaceutical Sciences Osaka University:the Second Osaka Police Hospital
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Kamada Akira
Faculty Of Pharmaceutical Science Osaka University
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Miyake Masatoshi
Faculty Of Pharmaceutical Sciences Osaka University
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NISHIHATA TOSHIAKI
Faculty of Pharmaceutical Sciences, Osaka University
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Nishihata Toshiaki
Faculty Of Pharmaceutical Science Osaka University
関連論文
- STUDY ON THE MECHANISM BEHIND ADJUVANT ACTION OF DIETHYLETHOXYMETHYLENE MALONATE ENHANCING THE RECTAL ABSORPTION OF CEFMETAZOLE AND LYSOZYME
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