EFFECTS OF PHENOTHIAZINES AND N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE ON RAT COLONIC ABSORPTION OF CEFMETAZOLE
スポンサーリンク
概要
- 論文の詳細を見る
Rat colonic absorption of cefmetazole was increased significantly by calmodulin inhibitors such as phenothiazines and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) when they were coadministered at a concentration between 1 and 100 μM. The bioavailability of cefmetazole, determined by area under the blood concentration curve method, increased 20 to 30% by the coadministration of calmodulin inhibitors. It is speculated that the enhancing action of agents on rat colonic absorption of cefmetazole takes place by a paracellular route and coadminstration of sodium ion increases their actions.
- 公益社団法人日本薬学会の論文
著者
-
Suzuka Takumi
大阪大学 薬
-
Nishihata T
Pharmacy Research Ibaraki Jpn
-
Kamada Akira
Faculty Of Pharmaceutical Sciences Osaka University:the Second Osaka Police Hospital
-
Kamada Akira
Faculty Of Pharmaceutical Science Osaka University
-
Furuya A
Interdisciplinary Graduate School Of Engineering Sciences Kyushu University
-
Furuya Atsushi
Faculty Of Pharmaceutical Sciences Osaka University
-
NISHIHATA TOSHIAKI
Faculty of Pharmaceutical Sciences, Osaka University
-
SUZUKA TAKUMI
Faculty of Pharmaceutical Sciences, Osaka University
-
Kamada A
Faculty Of Pharmaceutical Sciences Osaka University
-
Suzuka Takumi
Faculty Of Pharmaceutical Sciences Osaka University
-
Nishihata Toshiaki
Faculty Of Pharmaceutical Science Osaka University
関連論文
- STUDY ON THE MECHANISM BEHIND ADJUVANT ACTION OF DIETHYLETHOXYMETHYLENE MALONATE ENHANCING THE RECTAL ABSORPTION OF CEFMETAZOLE AND LYSOZYME
- EFFECT OF PHENOTHIAZINES, DISODIUM ETHYLENEDIAMINE-TETRAACETIC ACID AND DIETHYL MALEATE ON IN VITRO RAT COLONIC TRANSPORT OF CEFMETAZOLE AND INULIN
- EFFECTS OF PHENOTHIAZINES AND N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE ON RAT COLONIC ABSORPTION OF CEFMETAZOLE
- EFFECT OF POLYACRYLIC ACID GEL ON THE RECTAL ABSORPTION OF [Asu^]-EEL CALCITONIN IN RTS
- HISTOPATHOLOGIC CHANGES IN THE RECTAL MUCOSA AFTER ADMINISTRATION OF NON-STEROIDAL ANTI-INFLAMMATORY ANALGESIC SUPPOSITORIES IN RATS
- Linear Analysis of Neoclassical Tearing Mode based of the Four-Field Reduced Neoclassical MHD Equation
- Linear Analysis of Neoclassical Tearing Mode based on the Four-Field Reduced Neoclassical MHD Equation
- Tearing Mode Instability due to Anomalous Resistivity : Fluids, Plasmas, and Electric Discharges
- Tearing Mode Instability due to Anomalous Resistivity
- POSSIBLE MECHANISM REGULATING BARRIER FUNCTION OF RAT INTESTINAL MUCOSA AGAINST PERMEATION OF LIPOPHOBIC COMPOUND
- ENHANCED INTESTINAL ABSORPTION OF AMINO ACIDS AND AMINO ACID-LIKE DRUG BY POSSIBLE FORMATION OF ENAMINE IN ADMINISTERED SOLUTION BY THE PRESENCE OF ETHYLACETOACETATE
- EFFECT OF ADJUVANTS ON THE RECTAL ABSORPTION AND LYMPHATIC UPTAKE OF PEPLEOMYCIN IN RATS
- THE EFFECTS OF THE ADMINISTRATION ROUTES ON THE BILIARY EXCRETION OF ANTIBIOTICS
- DEVELOPMENT AND CLINICAL INVESTIGATION OF SODIUM DICLOFENAC SUSTAINED-RELEASE SUPPOSITORIES
- Rat Percutaneous Transport of Diclofenac and Influence of Hydrogenated Soya Phospholipids(Pharmaceutical)