Etude Structurale d'un Analogue de L'Ellipticine a Visee Antineoplasique le Dihydro-1, 4 oxo-4 Trimethyl-2,5,11-6H-pyrido[3,2-b]carbazole par Diffraction de Rayons. X(Physical,Chemical)

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概要

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• The synthesis of 1,4-dihydro-4-oxo-2,5,11-trimethyl-6H-pyrido[3,2-b]carbazole was described and the lactam-lactim tauromerism was discussed. C_<18>H_<16>N_2O crystallizes in space group P2_l/c with D_m=1.30(2) Mg・m^<-3> in accionitrile with a=16.179(4), b=14.900(3), c=12.702(3)Å, β=112.28(2)゜, V=2833.6Å^3, Z=8. The crystal structure was investigated by X-ray diffraction method with final R=0.04 for 2355 independent reflections. In the two molecules, the lactam form was observed while the lactim for was found with many derivatives as well in solid state as in solution. The carbazole ring is planar while the 1,4-dihydro-4-oxo-pyridine deviates from planarity. The molecules have rather small overlapping and the molecular packing involves many hydrogen bonds.

• 公益社団法人日本薬学会の論文
• 1987-05-25

著者

• Lancelot Jean-charles

  Laboratoire De Chimie Therapeutique

• Lancelot Jea.charles

  フランス

• Dung Nguyen

  Laboratoire De Chimie Minerale Et Structurale

• Dung Nguyenhuy

  Laboratoire De Chimie Minerale Et Structurale

• Dung N

  Univ. Caen Caen Fra

• Dung Nguyen

  Laboratoire De Chimie Minerale Et Structurale U.e.r. Des Sciences Pharmaceutiques

• Lancelot J‐c

  Centre D'etudes Et De Recherche Sur Le Medicament De Normandie (c.e.r.m.n.) Ufr Des Sciences Ph

• Rault Sylvain

  Laboratoire de Chimie Therapeutique, U.E.R. des Sciences Pharmaceutiques

• Robba Max

  Laboratoire de Chimie Therapeutique, U.E.R. des Sciences Pharmaceutiques

• VIOSSAT BERNARD

  Laboratoire de Chimie Generate, U.E.R. de Medicine et Pharmacite

• Robba M

  Centre D'etudes Et De Recherche Sur Le Medicament De Normandie Laboratoire De Pharmacochimie Uf

• Robba Max

  Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen

• Viossat Bernard

  Laboratoire De Chimie Generale

• Rault Sylvain

  C.e.r.m.n. Ufr. Des Sciences Pharmaceutiques

• Lancelot Jean-charles

  Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen

• DUNG NGUYEN-HUY

  Laburatoire de Chimie Mine-rale et Structurale, U.E.R. des Sciences Pharmciceutiques

• BENAZETH SIMONE

  Laboratoire de Physique, U.A. N゜ 200 au C.N.R.S., Faculte des Sciences Pharmaceutiques et Bilogiques

• Benazeth Simone

  Laboratoire De Physique U.a. N゜ 200 Au C.n.r.s. Faculte Des Sciences Pharmaceutiques Et Bilogiques U

関連論文

• EFFICIENT SYNTHESIS OF 6H-PYRIDO [3,2-b] CARBAZOLE DERIVATIVES FROM 3-AMINO-1,4-DIMETHYL CARBAZOLE(Communications to the Editor)
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• Pyrrolo [1', 2' : 1,2] pyrazino [6,5-b] carbazoles
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• Pharmacological Studies and Synthesis of Morpholino Alkyl Derivatives
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• Dihydro-5,6 oxo-6 pyrido [2,3-e] pyrrolo [1,2-a] pyrazine et Dihydro-5,6 oxo-6 pyrazino [2,3-e] pyrrolo [1,2-a] pyrazine
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