Pyridazino [4,5-b] carbazole : Synthese et Etude des Spectres de Resonance Magnetique Nucleaire
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概要
- 論文の詳細を見る
The acid anhydrides (5-7) were obtained by treatment of the corresponding 2,3-carbazoledicarboxylic acids (2-4) with acetic anhydride. Friedel-Crafts reaction of these anhydrides with benzene or toluene gave either 3-aroylcarbazole-2-carboxylic acids (8-11) or 6,7-phtaloylcar bazole (19-21) according to the reaction conditions. Treatment of the acids (8-11) with hydrazine hydrate gave 3,4-dihydro-4-oxo-pyridazino [4,5-b] carbazoles (14-17). When the anhydrides (5-7) were treated with hydrazine hydrate, the 1,2,3,4-tetrahydropyridazino [4,5-b]-carbazoles (26-28) were obtained. LiAlH_4 reduction of a diester (1) gave the corresponding 2,3-dihydroxymethyl derivative (23). When the latter compound was oxydized, the corresponding lactone (25) was resulted. The structure of all compounds was elucidated by means of elemental analyses, infrared (IR) and nuclear magnetic resonance (NMR) spectra.
- 公益社団法人日本薬学会の論文
- 1984-03-25
著者
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Lancelot Jean-charles
Laboratoire De Chimie Therapeutique
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Lancelot J‐c
Centre D'etudes Et De Recherche Sur Le Medicament De Normandie (c.e.r.m.n.) Ufr Des Sciences Ph
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Robba Max
Laboratoire de Chimie Therapeutique, U.E.R. des Sciences Pharmaceutiques
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Robba Max
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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Lancelot Jean-charles
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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LANDELLE HENRIETTE
Laboratoire de Chimie Therapeutique, U.E.R. des Sciences Pharmaceutiques, Universite de Caen
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Landelle Henriette
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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ROBBA MAX
Laboratoire de Chimie Therapeutique, U.E.R. des Sciences Pharmaceutiques, Universite de Caen
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