Synthese d'Aamino-4-[1] benzofuro [2,3-g] cinnolines
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概要
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The synthesis of the new heterocycles, 4-amino-[1] benzofuro [2,3-g] cinnolines, was accomplished by the intramolecular cyclization of the (Z) configuration of arylhydrazono-acetonitriles (5). The latter compounds were obtained via interaction between diazonium salt of 2-aminodibenzofuran (1) and various active methylene compounds following the Japp-KLINGEMANN reaction. The alkaline treatment of azo intermediates (4), which may be isolated in the course of condensation, gave the corresponding arylhydrazonoacetonitriles (5). A study of the configuration and possible isomerisation of 5 is reported. The linear structure of 4-amino-[1] benzofuro [2,3-g] cinnolines was elucidated by H-nuclear magnetic resonance.
- 公益社団法人日本薬学会の論文
- 1982-03-25
著者
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Ladure´e D
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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Robba Max
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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Laduree Daniel
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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