Structure Cristalline d'un Nouvel Agent Inotrope, la Bis-cyclopropylmethyl-1,4-piperazine (Bis-chlorhydrate)(Medicinal Chemistry,Chemical)

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概要

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• The crystal and molecular structure of 1,4-bis-(cyclopropylmethyl)piperazine dihydrochloride has been determined by single-crystal X-ray diffraction analysis. The crystals are monoclinic, space group P2_1/c, with a=11.641(7), b=7.017(2), c=9.32(4)Å, β=107.99(6)^6, Z=2. The structure was solved by direct methods. The hydrogen atoms were included in the refinement. The final R value is 0.035 for 1513 reflections considered to be observed. The bond distances and angles are in good agreement with the expected values. The 1,4-bis-eyclopropylmethylpiperazinium (2^+) ion has the "chair" conformation with a symmetry center. The crystal packing is due to the electrostatic attraction between chloride and nitrogen atoms, reinforced by hydrogen bonds.

• 公益社団法人日本薬学会の論文
• 1987-03-25

著者

• Dung Nguyen

  Laboratoire De Chimie Minerale Et Structurale

• Dung Nguyenhuy

  Laboratoire De Chimie Minerale Et Structurale

• Dung N

  Univ. Caen Caen Fra

• Dung Nguyen

  Laboratoire De Chimie Minerale Et Structurale U.e.r. Des Sciences Pharmaceutiques

• Robba Max

  Laboratoire de Chimie Therapeutique, U.E.R. des Sciences Pharmaceutiques

• VIOSSAT BERNARD

  Laboratoire de Chimie Generate, U.E.R. de Medicine et Pharmacite

• SEVRICOURT MICHEL

  Laboratorie de Chimie Therapeutique, U.E.R. den Sciences Pharmaceutiques

• Dung Nguyen

  Laboratoire De Cbimie Minerale Et Structurale

• Robba M

  Centre D'etudes Et De Recherche Sur Le Medicament De Normandie Laboratoire De Pharmacochimie Uf

• Robba Max

  Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen

• Viossat Bernard

  Laboratoire De Chimie Generale

• Sevricourt Michel

  Laboratorie De Chimie Therapeutique U.e.r. Den Sciences Pharmaceutiques

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