Synthesis of Benzofuro[3,2-f]pythalazine Derivatives
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概要
- 論文の詳細を見る
The reaction of hydrazine with dibenzofuran-1,2-dicarboxylic anhydrides followed by treatment with acetic acid resulted in the formation of 1,4-dioxo-1,2,3,4-tetrahydrobenzofuro[3,2-f]phthalazines. Dibenzofuran-1,2-dicarboxylic anhydrides were prepared by the Diels-Alder reaction of 2-alkenyl benzofurans and maleic anhydride followed by oxidative aromatization. Chlorination of 1,4-dioxo-1,2,3,4-tetrahydrobenzofuro[3,2-f]phthalazines and subsequent nucleophilic substitution afforded 1,4-dialkoxybenzofuro[3,2-f]phthalazines. These compounds were subjected to cytotoxicity assay against L1210 mice leukemia as analogues of methoxyllipticines.
- 公益社団法人日本薬学会の論文
- 1991-11-25
著者
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Robba M
Centre D'etudes Et De Recherche Sur Le Medicament De Normandie Laboratoire De Pharmacochimie Uf
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Robba Max
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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Laduree Daniel
Laboratoire De Chimie Therapeutique U.f.r. Des Sciences Pharmaceutiques Universite De Caen
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Laduree Daniel
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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Landelle H
Laboratoire De Chimie Therapeutique U.f.r. Des Sciences Pharmaceutiques Universite De Caen
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Landelle Henriette
Laboratoire De Chimie Therapeutique U.e.r. Des Sciences Pharmaceutiques Universite De Caen
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GODARD Anne-Marie
Laboratoire de Chimie Therapeutique, U.F.R. des Sciences Pharmaceutiques, Universite de Caen
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CHENU Edith
Institut de Cancerologie et d'Immunogenetique, Hopital Paul Brousse 14
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Chenu Edith
Institut De Cancerologie Et D'immunogenetique Hopital Paul Brousse 14
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Godard Anne-marie
Laboratoire De Chimie Therapeutique U.f.r. Des Sciences Pharmaceutiques Universite De Caen
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