アレルギー性薬疹における掻痒感の検討

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We examined the occurrence of itching in 310 patients in whom allergic drug eruption was suspected and studied various aspects of itching for 221 leukocyte migration test (LMT)-positive patients. The incidence of itching was 75.1% in the LMT-positives and 64.0% in LMT-negatives, a significant difference (p<0.05, Χ^2-test). In the former, there was a negative correlation between the incidence of itching and aging (correlation coefficient; r=-0.78, p<0.01). As regards latent period, the incidence of itching was 65.0% in less than 3 days and 83.0% in more than 4 days, and this difference was also significant (p<0.05, Χ^2-test). Regarding leucocyte migration factors (LMFs), there was a signifant difference between the incidence of itching for the leukocyte migration activating factor (LMAF) which was was 82.2% and that for the leukocyte migration inhibitory factor (LMIF) which was 69.2% (p<0.05, Χ^2-test). In terms of causative drugs, the incidence of itching was 80.2% for antibacterial drugs and 62.5% for non-steroidal anti-inflammatory drugs (NSAIDs), the difference again being significant (p<0.02, Χ^2-test). The detection rate of LMAF was significantly higher than that of LMIF for the antibacterial drugs (p<0.05, Χ^2-test), but in the case of NSAIDS, the LMIF detection rate was significantly higher than that for LMAF (p< 0.00001, Χ^2-test). Our findings indicate that the itching may arise as an allergic reaction in drug eruption and is present in 3/4 of allergic drug eruption cases. It also seems to be decreased by aging and to be influenced by the latent period, causative drug and LMFs.
日本医療薬学会の論文
2007-05-10

アレルギー性薬疹における掻痒感の検討

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