薬物アレルギー起因薬検出における白血球遊走試験(ケモタキシス・チャンバー法)の臨床的有用性の検討 : アガロース・プレート法とケモタキシス・チャンバー法の比較解析

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We performed a comparison between leukocyte migration tests performed by the chemotaxis chamber method (LMT-chamber) and the agarose plate method (LMT-agarose) to study the usefulness of the LMT-chamber method in the identification of causative drugs in drug allergies. For LMT-agarose, the positive rate among 210 patients suspected of hypersensitivity to drugs (subject patients) was 67.6% and for the LMT-chamber the positive rate among 197 subject patients was 81.2%, a significantly higher positive rate for the latter (p<0.001, χ^2-test). The positive rate for LMT-agarose was 6.9% in 102 patients without hypersensitivity to drugs (control patients)and 9.8% for the LMT-chamber in 82 control patients, but this difference was not significant. In addition, the LMT-chamber produced a higher positive rate than LMT-agarose for all hypersensitivity symptoms and all efficacy categories of the suspected drugs. It also produced a significantly higher positive rate than LMT-agarose in subject patients without addition of self serum (p<0.05, χ^2-test) and there were no significant differences between males and females or young and old persons, as there were in the case of LMT-agarose. Our findings indicate that the LMT-chamber may be more sensitive than LMT-agarose in identifying the causative drug in drug allergies and more useful than LMT-agarose for many hypersensitivity symptoms and suspected drugs. In addition, the LMT-chamber is much less influenced than LMT-agarose as regards patient's own serum, or by sex and age.
日本医療薬学会の論文
2009-02-10

薬物アレルギー起因薬検出における白血球遊走試験(ケモタキシス・チャンバー法)の臨床的有用性の検討 : アガロース・プレート法とケモタキシス・チャンバー法の比較解析

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