衝撃波DDS開発のためのマイクロカプセルの試作と力学的特性

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This paper describes prototype of microcapsule including a bubble for Shock Wave Drug Delivery Systems and evaluation of their mechanical properties. Microcapsules are generated by dropping mixed solution of Sodium Alginate and Polyvinyl Alcohol (PVA) into Calcium Chloride solution (CaCl_2) Young's modulus are estimated by an aspiration experiment and its numerical analysis. Liquid and gas are injected into the microcapsules on micromanipulation system by hand. The result showed that microcapsules generated by low concentration of Sodium Alginate, PVA, and CaCl_2 are able to be injected by micropipette and to make the microcapsule including a bubble. Furthermore, we found the existence of threshold value of apparent Young's modulus between able or disable of injection on the assumption of visco elasticity of microcapsule shell.
2005-07-25