1527 衝撃波DDS用機能性マイクロカプセルの開発(S32 DDSをめざした音響波や渦の応用,S32 DDSをめざした音響波や渦の応用)

概要

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This paper describes development of multifunctional microcapsules including chemotaxis and high permeability for drug delivery systems (DDS) using shock waves. In shock wave DDS, microcapsules including drug and bubbles in blood flow are disintegrated by shock wave near an affected part It is well known that neutrophils are moved to inflamed part by chemoattractant In order to make the neutrophil based capsule, we attempted to inject liquid and gas bubble into neutrophil using micromanipulation system in the microscope. As a experiment result, it was shown that the neutrophil disappeared by applying local force to membrane using micropipette. The nanosize capsule with alternative permeability is produced by N_2 gas, liposome solution liquid and ultrasonic waves. The size of the produced capsules was from 200 to 800nm in the conditions of ultrasound intensity 3-5 watt and working time 3-10 minutes.
2007-09-07