Development of Blood Analog Fluids Using Human Hair Protein Particles(<Special Issue>Bioengineering)
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概要
- 論文の詳細を見る
Model experiments of blood flow are very important in the study of mechanical aspects in cardiovascular research and the development of artificial organs. Several blood analog fluids, such as non-Newtonian fluids have been developed and used in model experiments. However, little is known about blood substitutes with biocompatible properties. We have developed novel procedures for preparing human hair protein films, and have fabricated protein particle suspensions from the films, by mechanical stimulation, for use as blood analog fluid. The average diameter of the protein particles was controlled and microscopic observations were done using a confocal microscope. The Casson's plot patterns of the suspension containing the protein particles were similar to those of human blood. The protein particles also worked well as ultrasound contrast agents in the ultrasound Doppler flow velocity measurements in the model experiments. Therefore, the protein particle system is a promising alternative for blood cells in artificial blood.
- 一般社団法人日本機械学会の論文
- 2005-12-15
著者
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Kobayashi Shunichi
Department Of Cardiology Kanagawa Cardiavascular Respiratry Center
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Ishii Shinji
Graduate School Of Engineering Shinshu University
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Kobayashi Shunichi
Shinshu University
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Morikawa Hirohisa
Shinshu University
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FUJII Toshihiro
Department of Kansei Engineering, Faculty of Textile Science and Technology, Shinshuu University
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Fujii Toshihiro
Shinshu Univ. Nagano Jpn
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Morikawa Hirohisa
Department Of Functional Machinery And Mechanics Faculty Of Textile Science And Technology Shinshu U
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Fujii T
Department Of Advanced Bioresources Science Graduate School Of Science And Technology Chiba Universi
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Kobayashi Shunichi
Department Of Functional Machinery And Mechanics Faculty Of Textile Science And Technology Shinshu U
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Fujii Toshihiro
Department Of Biological Science School Of Science Nagoya University Nagoya
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