A Clinicopathologic Study of Breast Cancer Patients during Pregnancy

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概要

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• Background & Aims: The purpose of this study was to investigate the influence of pregnancy on breastcancer prognosis by analyzing clinical and pathological features of young patients with breast cancer inrelation to last birth. Method: A total of 622 young breast cancer patients under 35 years of ageundergoing surgical treatment between 1960 and 1990 at Cancer Institute Hospital were included in thisstudy. The patients were classified into four groups; group A patients who were diagnosed duringpregnancy or within one year after delivery, group B patients who were diagnosed from one to three yearsafter delivery, group C patients who were diagnosed three years or more after delivery, and group Dpatients who were nulliparous. All four groups were examined from the viewpoint of clinical andpathological findings with regard to age, disease duration, first childbirth, clinical stage, histopathologicaltype, lymph node metastasis, and survival. Furthermore, nuclear grade and immunohistochemicalstaining of both estrogen receptor (ER) and factor-VIII were examined in early-stage breastcancer patients. Result: The incidence of early-stage(0, I and II) breast cancer was significantly(p＜0.05) lower in group A (69％) than in groups C (88％) and D (85％). The incidence of nodal involvementdecreased from group A (61％), B (59％), C (51％) to D (43％) in that order. The incidence ofnodal involvement in group D was significantly (p＜0.05) lower than that in groups A and B. Thepositive rate of estrogen receptor increased from group A (50％), B (56％) to C (72％) in that order. Disease-free survival was significantly (p＜0.05) more favorable in group D than in groups A and C. The similar result was obtained in patients with clinically early-stage breast cancer. Conclusion:Patients who developed breast cancer during pregnancy or within less than one year postpartum have apoor prognosis among patients under 35 years old. Patients having no childbirth history generally havea high risk factor of developing breast cancer, however, breast cancer patients without childbirth historyunder 35 years old result in a favourable prognosis.

• 北関東医学会の論文
• 2006-05-01

著者

• Sakamoto Goi

  Department of Surgery and Pathology, Cancer Institute Hospital

• Kasumi Fujio

  Department of Surgery and Pathology, Cancer Institute Hospital

• 三木 義男

  癌研ゲノムセンター

• 三木 義男

  東京医歯大 難治疾患研 疾患医科学研究系分子遺伝分野

• Yoshimoto M

  The Cancer Institute Of Japanese Foundation For Cancer Research (jfcr)

• 三木 義男

  東京医科歯科大学難治疾患研究所 分子遺伝分野

• Mishima Yuko

  Cancer Chemotherapy Center Clinical Chemotherapy Japanese Foundation For Cancer Research

• Matsumoto-mishima Yuko

  癌研究会癌化学療法センター 臨床研究部

• Yoshimoto Masataka

  Department of Surgery and Pathology, Cancer Institute

• Morishita Yasuo

  Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine

• Fukino K

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Kasumi Fujio

  Department Of Breast Surgery Cancer Institute Hospital

• Oyama T

  Department Of Pathology Dokkyo Medical School Of Medicine

• Oyama Tetsunari

  Department Of Pathology Dokkyo University School Of Medicine

• Horiguchi Jun

  Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine

• Iijima Kotaro

  Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine

• Horiguchi Jun

  Department Of Thoracic And Visceral Organ Surgery Graduate School Of Medicine Gunma University

• Horiguchi Jun

  Department Of Psychiatry And Neurosciences Hiroshima University School Of Medicine

• Iijima Kotaro

  Department Of Breast Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research

• Kasumi Fujio

  Department Of Breast Surgery The Cancer Institute Hospital Of Jfcr

• Sakamoto Goi

  Department Of Breast Pathology The Cancer Institute Of Japanese Foundation For Cancer Research

• Sakamoto Goi

  Department Of Breast Pathology Cancer Institute

• Miki Yoshio

  Department Of Molecular Diagnosis Cancer Institute Japanese Foundation For Cancer Research

• Morishita Yasuo

  Department Of Thoracic And Visceral Organ Surgery Gunma University Graduate School Of Medicine And F

• Oyama Tetsunari

  Department Of Pathology Dokkyo Medical School Of Medicine

• Fukino Koichi

  Department Of Neurosurgery Nippon Medical School

• Iijima Kousaku

  Department Of Surgery Tomioka Public General Hospital

• Morishita Yasuo

  Department Of Technical Support Ube National College Of Technology

• Morishita Yasuo

  Second Department Of Surgery Faculty Of Medicine Gunma University

• Miki Yoshio

  Department Of Human Genome Analysis Cancer Chemotherapy Center Japanese Foundation For Cancer Resear

• Iijima Kohtaro

  Department Of Breast Oncology Cancer Institute Hospital

• Oyama Tetsunari

  Department Of Diagnostic Pathology Gunma University Graduate School Of Medicine

• Morishita Yasuo

  Second Department Of Surgery

• Yoshimoto Masataka

  Department Of Molecular Diagnosis Cancer Institute Japanese Foundation For Cancer Research

• Horiguchi Jun

  Department Of Clinical Radiology Hiroshima University Hospital Hiroshima University

• Horiguchi Jun

  Department Of Clinical Radiology Hiroshima University Hospital

• Iijima Kotaro

  Department Of Breast Oncology Cancer Institute Hospital

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