神経細胞樹状突起の電気的興奮性,シナプス可塑性,局所回路の動態 : AタイプK^+チャネルの機能的役割(<小特集>ニューロプラットフォームシミュレーション)

概要

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We investigated the role of A-type K channels in the neuronal dendritic function. In the first half, the contribution of these channels to the induction of long-term potentiation (LTP) in hippocampal CA1 pyramidal neurons was examined experimentally. The results supported the hypothesis that A-type K channels contribute to the induction of LTP through controlling the dendritic intergration properties. In the second half, by using the NEURON simulator, we tried to elucidate mechanisms of boosting for EPSP amplitudes and inhibiting for ones. Here, it was theoretically demonstrated that the super-sensitivity, which can be controlled by the down-regulation of the A-type K channel, is the fundamental mechanism for regulation of such membrane responses.
2006-03-15