A Pathology Study of Malignant and Benign Ovarian Tumors Among Atomic-Bomb Survivors : Case Series Report
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概要
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The present article describes the series of incident primary ovarian tumors in the Life Span Study (LSS) cohort of the Radiation Effects Research Foundation, with particular emphasis on case ascertainment and characterization of histological features of the tumors. We identified 723 ovarian tumors (260 malignant, 463 benign) in 648 individuals of about 70,000 female LSS subjects; 71 cases had more than one ovarian tumor. We histologically confirmed 601 tumors (182 malignant, 419 benign tumors). The most frequent histological type was common epithelial tumor (90.7% for malignant and 59.7% for benign tumors). The distributions of ovarian tumors by histological type were similar to those from other studies. Among malignancies, the frequency of common epithelial types relative to other tumor types increased with radiation dose (p=0.02). Among benign tumors, the relative frequency of sex-cord stromal tumors increased with radiation dose (p=0.04). The women with mucinous cancer had better survival than those with serous cancers (p=0.03). Within tumor types, there was no consistent pattern of survival by radiation dose. Variations in histological types of ovarian tumors in response to radiation dose, suggested by the case series data need to be followed up by population-based incidence analysis.
- 日本放射線影響学会の論文
- 2006-03-31
著者
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LAND CHARLES
Radiation Epidemiology Branch, NCI, Bethesda
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SHIMIZU Yukiko
Department of Obstetrics and Gynecology, Kameda Medical Center
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INAI Kouki
Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University
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Soda Midori
Department of Epidemiology, Radiation Effects Research Foundation, Nagasaki
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Inai Kouki
Department Of Pathology Division Of Medical Intelligence And Informatics Programs For Applied Biomed
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KAWAI KIOKO
Department of Pathology, Nagasaki Municipal Hospital
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MABUCHI Kiyohiko
Radiat. Effects Res. Found.
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Land Charles
Radiation Epidemiology Branch Division Of Cancer Epidemiology And Genetics National Cancer Institute
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Shimizu Yukiko
Department Of Biochemistry Teikyo University School Of Medicine
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Shimizu Yukiko
Department Of Epidemiology Radiation Effects Research Foundation Hiroshima And Nagasaki
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Kawai Kioko
Department Of Pathology 2 Nagasaki University
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Kawai Kioko
Department Of Pathology Nagasaki General Health Center
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Soda Midori
Department Of Epidemiology Radiation Effects Research Foundation
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Soda Midori
Department Of Epidemiology Radiation Effects Research Foundation Hiroshima And Nagasaki
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Land C
Radiation Epidemiology Branch Division Of Cancer Epidemiology And Genetics National Cancer Institute
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Mabuchi K
Radiation Epidemiology Branch Division Of Cancer Epidemiology And Genetics National Cancer Institute
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TOKUNAGA Masayoshi
Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima and Nagasaki
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TOKUOKA Shoji
Radiation Effects Research Foundation
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Tokunaga Masayoshi
Department Of Epidemiology Radiation Effects Research Foundation Hiroshima And Nagasaki
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Tokuoka Shoji
Epidemiology Radiation Effects Research Foundation
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Shimizu Yukiko
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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