Liver Cancer in Atomic-bomb Survivors: Histological Characteristics and Relationships to Radiation and Hepatitis B and C Viruses

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概要

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• Histological features of primary liver cancer among atomic-bomb survivors and their relationship to hepatitis B (HBV) and C viral (HCV) infections are of special interest because of the increased risk of liver cancer in persons exposed to ionizing radiation and the high and increasing liver cancer rates in Japan and elsewhere. We conducted a pathology review of liver cancers occurring from 1958 to 1987 among subjects in the 120,321 member cohort of 1945 Hiroshima and Nagasaki residents. A panel of pathologists classified tumor histological types and defined accompanying cirrhotic changes of the liver. Archival tissue samples were assessed for HBV using pathology stains and PCR. Reverse transcriptase (RT) PCR was used to determine HCV status. We used unconditional logistic regression to compare 302 hepatocellular carcinoma (HCC) cases to 53 cholangiocarcinoma (CC) cases, adjusting for age, year of diagnosis, sex and viral status. Cirrhotic changes occurred significantly more often among HCC than CC cases (76% in HCC and 6% in CC). Compared to CC cases, HCC cases were 10.9 times more likely to be HBV-positive (95% confidence interval: 2.1-83.2) and 4.3 times more likely to be HCV-positive (95% confidence interval: 1.1-20.5). No significant differences were found between HCC and CC cases in radiation exposures. The predominance of HCC in the atomic-bomb survivors follows the background liver cancer pattern in Japan. Our findings suggest that HBV and HCV are involved in the pathogenesis of HCC with or without cirrhosis and are significantly less important in that of CC.

• 日本放射線影響学会の論文

著者

• Cologne John

  Statiscs, RERF

• Soda Midori

  Department of Epidemiology, Radiation Effects Research Foundation, Nagasaki

• Cologne J

  Radiation Effects Res. Foundation Hiroshima Jpn

• Itakura Hideyo

  Department Of Pathology Institute Of Tropical Medicine Nagasaki University

• Fujita Yasuyuki

  Epidemiology Radiation Effects Research Foundation

• Sharp G

  Radiation Effects Res. Foundation Hiroshima Jpn

• FUKUHARA Toshiyuki

  Department of Applied Biological Sciences, Faculty of Agriculture, Tokyo University of Agriculture a

• Soda Midori

  Department Of Epidemiology Radiation Effects Research Foundation

• Soda Midori

  Department Of Epidemiology Radiation Effects Research Foundation Hiroshima And Nagasaki

• Mizuno Terumi

  Radiobiology Radiation Effects Research Foundation

• Mabuchi K

  Radiation Epidemiology Branch Division Of Cancer Epidemiology And Genetics National Cancer Institute

• Fukuhara Toshiyuki

  Department Of Pathology Hiroshima Prefectural Hospital

• Fukuhara Toshiyuki

  Department Of Applied Biological Sciences Tokyo University Of Agriculture And Technology

• TOKUNAGA Masayoshi

  Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima and Nagasaki

• TOKUOKA Shoji

  Radiation Effects Research Foundation

• SHARP GERALD

  Epidemiology, Radiation Effects Research Foundation

• YAMAMOTO MASAMI

  Department of Hospital Pathology, Hiroshima University Hospital

• TOKUOKA SHOJI

  Epidemiology, Radiation Effects Research Foundation

• MABUCHI KIYOHIKO

  Epidemiology, Radiation Effects Research Foundation

• Tokunaga Masayoshi

  Department Of Epidemiology Radiation Effects Research Foundation Hiroshima And Nagasaki

• Tokuoka Shoji

  Epidemiology Radiation Effects Research Foundation

• Yamamoto M

  Department Of Hospital Pathology Hiroshima University Hospital

• Yamamoto Masami

  Department Of Applied Physics Tohoku University

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