Myelodysplastic Syndromes in Atomic Bomb Survivors in Nagasaki: A Preliminary Analysis
スポンサーリンク
概要
- 論文の詳細を見る
Myelodysplastic syndromes (MDS) are a heterogenous hematological group characterized by an ineffective hematopoiesis resulting in a variety of cytopenias, morphological abnormalities of blood cells, chromosomal aberrations, and an increases risk of transformation into acute myeloid leukemia. Despite of its nature of close relation to leukemia, MDS has been not well investigated in atomic bomb (A-bomb) survivors. We conducted a retrospective cohort study with over 80,000 A-bomb survivors in Nagasaki to assess the incidence of MDS and its relation with A-bomb exposure status. In a preliminary analysis, we confirmed 162 MDS cases during 1980 to 2004. The median age at diagnosis was 71 years old. The incidence rate was higher in men than women, and an inverse relationship was observed between incidence of MDS and the distance from the hypocenter. We suggest that A-bomb radiation may affect the occurrence of MDS in A-bomb survivors even more than 50 years passed after the explosion. Further detail analyses are necessary to confirm these results.
- 長崎大学の論文
著者
-
IWANAGA Masako
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
-
Iwanaga Masako
Department Of Hematology And Molecular Medicine Nagasaki University Graduate School Of Biomedical Sc
-
Atogami Sunao
Department Of Hematology Nagasaki Municipal Medical Center
-
Soda Midori
Department of Epidemiology, Radiation Effects Research Foundation, Nagasaki
-
Koba Takashi
Department of Internal Medicine, Nagasaki Atomic Bomb Casualty Council Health Management Center
-
Yamamura Masanori
Department of Hematology, Nagasaki Municipal Hospital
-
Morita Saburo
Department of Hematology, Japanese Red-Cross Nagasaki Atomic Bomb Hospital
-
Yoshida Yoshiharu
Department of Internal Medicine, St. Francis Hospital
-
Iwanaga Masako
Department Of Hematology Atomic Bomb Disease Institute Nagasaki University Graduate School Of Biomed
-
Yoshida Yoshiharu
Department Of Internal Medicine St. Francis Hospital
-
Soda Midori
Department Of Epidemiology Radiation Effects Research Foundation
-
Soda Midori
Department Of Epidemiology Radiation Effects Research Foundation Nagasaki
-
Koba Takashi
Department Of Internal Medicine Nagasaki Atomic Bomb Casualty Council Health Management Center
-
Yamamura Masanori
Department Of Hematology Nagasaki Municipal Hospital
-
Morita Saburo
Department Of Hematology Japanese Red-cross Nagasaki Atomic Bomb Hospital
-
Yamamura Masaomi
Department of Hematology, Nagasaki Municipal Hospital
-
Momita Saburo
Department of Hematology, Japanese Red-Cross Nagasaki Atomic Bomb Hospital
-
Joh Tatsuro
Department of Internal Medicine, St. Francis Hospital
-
MOMITA Saburo
Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
関連論文
- Long-term efficacy of imatinib in a practical setting is correlated with imatinib trough concentration that is influenced by body size : a report by the Nagasaki CML Study Group
- Imatinib Provides Durable Molecular and Cytogenetic Responses in a Practical Setting for Both Newly Diagnosed and Previously Treated Chronic Myelogenous Leukemia : A Study in Nagasaki Prefecture, Japan
- Multicenter Prospective Study of Clonal Complications in Adult Aplastic Anemia Patients following Recombinant Human Granulocyte Colony-Stimulating Factor (Lenograstim) Administration
- Myelodysplastic Syndromes in Atomic Bomb Survivors in Nagasaki: A Preliminary Analysis
- Recovery of Hematopoietic Progenitor Cells in Patients With Severe Aplastic Anemia Who Obtained Good Clinical Response With a Combination Therapy of Immunosuppressive Agents and Recombinant Human Granulocyte Colony-Stimulating Factor
- Men With Brugada-Like Electrocardiogram Have Higher Risk of Prostate Cancer(Arrhythmia/Electrophysiology)
- Fatty Liver and Uric Acid Levels Predict Incident Coronary Heart Disease but Not Stroke among Atomic Bomb Survivors in Nagasaki
- Basic Characteristics of Chronic Hypotension Cases : A Longitudinal Follow-Up Study from 1958 through 1999
- Effects of Radiation on Fatty Liver and Metabolic Coronary Risk Factors among Atomic Bomb Survivors in Nagasaki
- Trends in the seroprevalence of HTLV-1 in Japanese blood donors in Nagasaki Prefecture, 2000-2006.
- Correlation berween Fatty Liver and Coronary Risk Factors : a Population Study of Elderly Men and Women in Nagasaki, Japan
- Multiple Primary Cancers in Nagasaki Atomic Bomb Survivors
- Pulmonary Sarcoidosis Showing a Solitary Large Nodule with a "Pseudo-alveolar" Pattern
- Prosthetic Valve Endocarditis Due to Candida Albicans Treated Successfully with Medical Treatment Alone
- Human T-Lymphotropic Virus Type-I Infection, Antibody Titers and Cause-specific Mortality among Atomic-bomb Survivors
- Human T-cell lymphotropic virus type-1 infection and risk of cancer : 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan
- A Pathology Study of Malignant and Benign Ovarian Tumors Among Atomic-Bomb Survivors : Case Series Report
- Isolation and Identification of 3-O-Methyl-D-galactose as a Constituent of Neutral Polysaccharide of Chlorella vulgaris
- Liver Cancer in Atomic-bomb Survivors: Histological Characteristics and Relationships to Radiation and Hepatitis B and C Viruses
- Intensified consolidation therapy with dose-escalated doxorubicin did not improve the prognosis of adults with acute lymphoblastic leukemia : the JALSG-ALL97 study
- Tumor Registries and Cancer Incidence Studies : II. BIOLOGICAL EFFECTS
- Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts.
- Heterogeneity in clonal nature in the smoldering subtype of adult T-cell leukemia : continuity from carrier status to smoldering ATL
- A Case of .BETA.-thalassemia with a C.RAR.T Substitution at Position 654 of the Second Intervening Sequence of the .BETA.-globin Gene.