Trends in the seroprevalence of HTLV-1 in Japanese blood donors in Nagasaki Prefecture, 2000-2006.
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概要
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The original publication is available at www.springerlink.comHuman T cell leukemia virus type-1 (HTLV-1) is the established cause of adult T cell leukemia/lymphoma. Monitoring time trends in HTLV-1 seroprevalence in blood donors is important to assess the safety of the blood supply in the viral endemic area. We analyzed changes in HTLV-1 seroprevalence in 48415 first-time blood donors who donated blood from 2000 to 2006 in Nagasaki prefecture, an endemic area in Japan. The donors were divided into 10-year birth cohorts: before 1950, 1951-1960, 1961-1970, 1971-1980, and 1981-1990. Among the first-time blood donors, 622 were tested positive for HTLV-1 [overall seroprevalence: 1.28%, (95% CI 1.19-1.39)]. Seroprevalence was significantly high in the birth cohort of before 1950 (6.22%) and declined with birth-year. The time trend of the birth-cohort-specific seroprevalence showed almost no change within each birth cohort, except for the birth cohort of 1981-1990 that showed a significantly declining trend (P for trend = 0.006). Among the birth cohort of 1981-1990, the seroprevalence was stable among those born during 1981-1986 (0.66-0.83%), but was lower among those born during 1987-1990 (0-0.38%). Detail analyses showed that HTLV-1 seroprevalence among blood donors clearly declined in those born after 1987.
- Japanese Society of Hematology,日本血液学会の論文
- 2009-09-15
著者
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KAMIHIRA Shimeru
Department of Laboratory Medicine, Nagasaki University School of Medicine
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IWANAGA Masako
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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Iwanaga Masako
Department Of Hematology And Molecular Medicine Nagasaki University Graduate School Of Biomedical Sc
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Kamihira Shimeru
Department Of Laboratory Medicine Nagasaki University Graduate School Of Biomedical Sciences
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CHIYODA Shin
The Nagasaki Red Cross Blood Center
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KUSABA Eisuke
The Sasebo Red Cross Blood Center
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