Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma

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概要

• 論文の詳細を見る

• The distinction between epithelioid mesothelioma and lung adenocarcinoma remains an important diagnostic challenge for surgical pathologists. The aim of the present study was to select a limited and appropriate panel of antibodies that can differentiate between epithelioid mesothelioma and lung adenocarcinoma. Specimens of 90 epithelioid mesotheliomas and 51 lung adenocarcinomas obtained from Japanese cases were examined using calretinin, WT1, AE1/AE3, CAM5.2, cytokeratin (CK) 5/6, vimentin, epithelial membrane antigen (EMA), thrombomodulin, CEA, CA19-9, and CA125. Ninety-six percent of epithelioid mesotheliomas were positive for calretinin; 99% for WT1; 100% for AE1/AE; 97% for CAM5.2; 70% for CK 5/6; 91% for vimentin; 96% for EMA; 71% for thrombomodulin; 77% for mesothelin; 7% for CEA; 17% for CA19-9; and 85% for CA125. In contrast, 33% of lung adenocarcinomas were positive for calretinin; 16% for WT1; 100% for AE1/AE3, CAM5.2, and EMA; 41% for CK 5/6; 47% for vimentin; 20% for thrombomodulin; 69% for mesothelin; 98% for CEA; 73% for CA19-9; and 80% for CA125. For distinguishing between epithelioid mesothelioma and lung adenocarcinoma, the combination of CEA, calretinin and each WT1 or thrombomodulin was suggested to be the best panel of immunohistochemical markers.

• Blackwell Publishingの論文
• 2007-04-01

著者

• Amatya VJ

  広島大学大学院医歯薬学総合研究科病理学

• Jeet Amatya

  広島大学大学院医歯薬学総合研究科病理学

• AMATYA Vishwa

  Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University

• TAKESHIMA Yukio

  Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University

• INAI Kouki

  Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University

• Inai Kouki

  Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University

• Inai K

  Second Department Of Pathology Hiroshima University School Of Medicine

• Inai Kouki

  Department Of Pathology Division Of Medical Intelligence And Informatics Programs For Applied Biomed

• Inai Kouki

  2nd Dept.pathol.hiroshima Univ.

• Amatya Vishwa

  Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University

• Jeet Amatya

  Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University

• KUSHITANI Kei

  Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University

• FURONAKA Osamu

  Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University

• SAKATANI Akio

  Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University

• Takeshima Y

  広島大学 医歯学総合研究科病理学

• Takeshima Yukio

  Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University

• Kushitani Kei

  Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University

• Sakatani Akio

  Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University

• Furonaka Osamu

  Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University

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