Genetic Alterations in Ovarian Mucinous Tumors : With Special Reference to the Histogenesis

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概要

• 論文の詳細を見る

• Morphological observations have indicated that there are two mechanisms in the human carcinogenesis : de novo carcinogenesis and multistep carcinogenesis through preneoplastic lesions. Recent molecular pathological techniques have made it possible to precisely analyze the step of the genetic event in the carcinogenetic process. Here, we report molecular pathological results suggesting multistep carcinogenesis in ovarian mucinous tumors. Specimens of 44 ovarian mucinous tumors, including 15 mucinous cystadenomas, 19 mucinous cystic tumors of borderline malignancy and 10 mucinous adenocarcinomas, were collected from our surgical files. Immunohistochemical analyses, including p53, ki-67, p21 / WAF1, cyclin D1 and c-erbB2, were performed. Loss of heterozygosity using 7 microsatellite markers and K-ras point mutation were examined. Furthermore, the correlation between the histological and genetic heterogeneities was analyzed. It was found that p53, Ki-67, and c-erbB2 expressions increased according to the histological grade as well as the frequency of genetic abnormalities. Histological heterogeneities were relatively well-correlated with the genetic heterogeneities. These results suggest that there is a subset of ovarian mucinous tumors in which there is an accumulation of genetic abnormalities.

• 日本組織細胞化学会の論文

著者

• INAI Kouki

  Second Department of Pathology, Hiroshima University School of Medicine

• TAKESHIMA Yukio

  Second Department of Pathology, Hiroshima University School of Medicine

• Inai Kouki

  Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University

• Inai K

  Second Department Of Pathology Hiroshima University School Of Medicine

• Inai Kouki

  Second Department Of Pathology Hiroshima University

• Takeshima Y

  広島大学 医歯学総合研究科病理学

• Takeshima Yukio

  Second Department Of Pathology Hiroshima University School Of Medicine

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