STRESSFUL LIFE EVENTS AS RISK FACTORS FOR DEVELOPMENT OF ALZHEIMER'S DISEASE : COMPARISON WITH PARKINSON'S DISEASE

概要

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To establish which risk factors might contribute to the development of Alzheimer' s disease (AD) and to clarify whether an association exists between AD and stressful life events, we conducted a retrospective case-control study involving 37 patients with a clinical diagnosis of AD and 37 patients with a clinical diagnosis of Parkinson's disease (PD). A structured direct interview with patients or surrogate respondents was used to gather information concerning the life events that might have caused mental shock and overload, as well as any history of head injury or chronic headache. Thirty-one AD patients (83.8%) had experienced various kinds of mental hardship within the 5 years [mean (SD), 1.5(1.0) years] before disease onset, the same was true of only 8 PD patients (21.6%). There was a significant association between AD and stressful life events (p<0.001) but not between AD and head injury or chronic headache. Stressful life events may contribute to the clinical onset of AD. They may play a key role in the development of AD but do not appear related to the development of PD.
名古屋市立大学の論文
2005-05-31