Activation of Nuclear Factor- B/Rel Proteins by Human T-Cell LeukemiaVirus Type I
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概要
- 論文の詳細を見る
Human T-Cell leukemia virus type I (HTLV-I) is a human retrovirus that is associated with the development of adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis. The 40 kDa viral protein Tax is thought to play a critical role in the development of these diseases since it transforms human T lymphocytes in vitro, and induces various types of tumors in transgenic animals carrying tax gene. Tax was originally identified as the transcriptional activator of its own viral promoter in a long terminal repeat. Thereafter, Tax has been shown to dysregulate cellular growth control mechanisms by affecting the transcription of cellular genes. Tax does not bind directly to DNA, but instead interacts with cellular factors to modulate their activities. Host transcription factors whose activity is modulated by Tax include nuclear factor (NF)-κB/Rel. NF-κB/Rel transcription factors participate in the activation of numerous genes involved in immune regulation/inflammation as well as cellular growth control including genes encoding cytokines, cell surface receptors, adhesion molecules, and acute phase proteins. This article reviews the molecular mechanisms of Tax that affect NF-κB/Rel activity and the role of NF-κB/Rel in the regulation of celular genes expression as well as cellular transformation by HTLV-I. In addition, we present a possible alternative mechanism involved in the Tax-independent activation of NF-κB/Rel in ATL cells in vivo, which might be involved in the late stages of leukemogenesis.
- 新潟大学の論文
著者
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Fujii Masahiro
Department Of Cardiology Nippon Medical School
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Mori Naoki
長崎大学熱帯医学研究所
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Naoki MORI
Department of Preventive, Medicine and AIDS Research, Institute ofTropical Medicine, Nagasaki Univer
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Naoki YAMAMOTO
Department of Preventive, Medicineand AIDS Research, Institute of Tropical Medicine, Nagasaki Univer
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Masahiro FUJI
Department of Virology, Niigata University School of Medicine
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Masahiro Fuji
Department Of Virology Niigata University School Of Medicine
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Mori Naoki
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
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Yamamoto N
Department Of Preventive Medicineand Aids Research Institute Of Tropical Medicine Nagasaki Universit
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Yamamoto Naoki
Department Of Bioinformatics Faculty Of Engineering Soka University
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