Diurnal Variation in Neutrophil Function
スポンサーリンク
概要
- 論文の詳細を見る
Neutrophil functions, including chemotaxis, reactive oxygen species (ROS)-producing capacity of neutrophils, and serum opsonic activity were investigated in 9 young healthy male volunteers. Venous blood of these volunteers was obtained under standardized conditions at 4-h intervals over a 24-h span. Neutrophil chemotaxis was evaluated by a modified Boyden technique, ROS-producing capacity of neutrophils and serum opsonic activity were measured by a simultaneous multiple measurement system based on luminol-dependent chemiluminescence and indicated by peak height and peak time. ROS-producing capacity of neutrophils and serum opsonic activity were activated in the daytime, and decreased from night to morning. There were negative correlations between the peak time of the luminol-dependent chemiluminescent response, neutrophil number (p<0.01) and segmented neutrophil number (p<0.01). On the other hand, no significant correlations were noted between serum opsonic activity and IgG, IgA, IgM, C3 or C4. In contrast, the peaks of neutrophil chemotaxis were at the wake-up time (6 : 00a.m.) and in the evening (6 : 00p.m.). This study indicates that diurnal variation of neutrophil function exists.
- 日本衛生学会の論文
著者
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KIKUCHI Takashi
Department of Electrical and Electronic Engineering, Utsunomiya University
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NAKAJI SHIGEYUKI
Department of Public Health, Hirosaki University School of Medicine
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ABE Tatsuya
Department of Neurosurgery, Oita Medical University
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Abe Tatsuya
Department Of Neurosurgery Oita University School Of Medicine
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SUZUKI KATSUHIKO
Department of Hygiene, Hirosaki University School of Medicine
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SUGAWARA KAZUO
Department of Hygiene, Hirosaki University School of Medicine
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Sugawara K
Department Of Hygiene Hirosaki University School Of Medicine
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Nakaji S
Department Of Hygiene Hirosaki University School Of Medicine
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Nakaji Shigeyuki
Department Of Hygiene Hirosaki University School Of Medicine
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Nakaji Shigeyuki
Dept. of Hygiene, Hirosaki University School of Medicine
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SHIRAISHI Masahiko
Department of Hygiene, Hirosaki University School of Medicine
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SATOH Hideki
Department of Hygiene, Hirosaki University School of Medicine
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Nakaji S
Hirosaki Univ. School Of Medicine Hirosaki Jpn
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Sugawara Kazuo
Department Of Hygiene Hirosaki University School Of Medicine
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Kikuchi Takashi
Department Of Cardiovascular Medicine Aomori Prefectural Central Hospital
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Shiraishi Masahiko
Department Of Hygiene Hirosaki University School Of Medicine
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Suzuki Katsuhiko
Dept. Of Hygiene Hirosaki University School Of Medicine
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Saito K
Department Of Hygiene Hirosaki University School Of Medicine
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Satoh Hideki
Department Of Electrical Engineering Ashikaga Institute Of Technology
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Kikuchi Takashi
Department Of Hygiene Hirosaki University School Of Medicine
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Kikuchi Takashi
Department Of Applied Science Tokyo Electrical Engineering College
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Abe Tatsuya
Department Of Hygiene Hirosaki University School Of Medicine
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Abe Tatsuya
Department Of Biochemistry Kyushu University School Of Medicine
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Satoh Hideki
Department Of Hygiene Hirosaki University School Of Medicine
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