Characteristics of Attenuating Effects of Rebamipide, an Anti-ulcer Agent, on Oxidative Burst of Human Neutrophils

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概要

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• The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). Rebamipide inhibited the LmCL response stimulated with opsonized zymosan, 12-myristate 13-acetate phorbol, and calcium ionophore in a dose-dependent manner, but the LgCL response was inhibited when neutrophils were stimulated with opsonized zymosan. LmCL response was also dose-dependently attenuated by rebamipide even in the presence of cimetidine. Thus, addition of rebamipide to H2-receptor antagonists can be considered for the treatment of gastric mucosal injury associated with oxidative stress.

• 社団法人 日本薬理学会の論文
• 2003-02-01

著者

• Liu Qiang

  Department Of Hygiene Hirosaki University School Of Medicine

• Liu Qiang

  弘前大学 1内

• Fukuda Yoshihiro

  Department Of Internal Medicine Kawasaki Hospital Kawasaki Medical School

• Fukuda Y

  Division Of Lower Gastroenterology Department Of Internal Medicine Hyogo College Of Medicine

• NAKAJI SHIGEYUKI

  Department of Public Health, Hirosaki University School of Medicine

• SHIMOYAMA TADASHI

  First Department of Internal Medicine, Hirosaki University School of Medicine

• FUKUDA SHINSAKU

  First Department of Internal Medicine, Hirosaki University School of Medicine

• SUGAWARA KAZUO

  Department of Hygiene, Hirosaki University School of Medicine

• Sugawara K

  Department Of Hygiene Hirosaki University School Of Medicine

• Sugawara K

  Graduate School Of Agricultural Science Tohoku University

• Nakaji S

  Department Of Hygiene Hirosaki University School Of Medicine

• Nakaji Shigeyuki

  Department Of Hygiene Hirosaki University School Of Medicine

• Fukuda S

  First Department Of Internal Medicine Hirosaki University School Of Medicine

• Fukuda Shinsaku

  First Department Of Internal Medicine Hirosaki University School Of Medicine

• NAKAMURA Seiichi

  Health Research Foundation

• Fukuda Yoshihiro

  Department Of Clinical Nutrition And Health Science Hyogo College Of Medicine

• Fukuda Yoshihiro

  Department Of Gastroenterology Hyogo Medical College

• Fukuda Sanae

  First Department Of Internal Medicine Hirosaki University School Of Medicine

• Nakaji S

  Hirosaki Univ. School Of Medicine Hirosaki Jpn

• Sugawara Kazuo

  Department Of Hygiene Hirosaki University School Of Medicine

• Liu Qiang

  Department Of Biological Sciences And Biotechnology Tsinghua University

• Shimoyama Takashi

  Department Of Internal Medicine Hyogo College Of Medicine

• Fukuda Y

  Department Of Clinical Nutrition And Health Science Hyogo College Of Medicine

• Nakamura Seiichi

  Department Of Social Medicine Hirosaki University Graduate School Of Medicine

• Shimoyama Tadashi

  Hirosaki Univ. School Of Medicine Hirosaki Jpn

• Shimoyama Tadashi

  First Department Of Internal Medicine Hirosaki University School Of Medicine

• Saito K

  Department Of Hygiene Hirosaki University School Of Medicine

• Shimoyama Tadashi

  Department Of Gastroenterology Hirosaki University Graduate School Of Medicine

• Shimoyama Tadashi

  Department Of Gastroenterology And Hematology Hirosaki University Graduate School Of Medicine

• Fukuda Shinsaku

  Department Of Gastroenterology Hirosaki University Graduate School Of Medicine

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