Diagnostic Accuracy of the E-Plate Serum Antibody Test Kit in Detecting Helicobacter pylori Infection Among Japanese Children
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概要
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Background: A number of noninvasive diagnostic tests are available to detect Helicobacter pylori infection. Data on serologic testing of children are lacking, however, and thus it remains unclear whether the serology cutoff points used for adults are appropriate for children.<BR>Methods: Serum and stool samples were obtained from 73 children who visited 5 hospitals in Japan between March 1993 and December 2009. Analysis of stool samples was carried out using an H pylori stool antigen enzyme-linked immunosorbent assay (HpSA ELISA), and serum antibodies to H pylori were examined using an antibody determination kit (E-Plate Eiken H pylori antibody). The validity of the serologic test was evaluated based on its sensitivity, specificity, and receiver operating characteristics curve.<BR>Results: Of the 73 children included in this study, 34 were HpSA-positive and 39 were negative. Among the 34 HpSA-positive patients, 32 were IgG-positive and 2 were IgG-negative. Of the 39 patients who were HpSA-negative, 38 were IgG-negative and 1 was IgG-positive. The sensitivity, specificity, and positive likelihood ratio for IgG antibody testing were 91.2%, 97.4%, and 35.6, respectively, based on the recommended adult cutoff point of 10 U/ml. Among children, use of cutoff points in the range of 7 to 9 U/ml yielded optimal values for sensitivity and specificity, as well as a positive likelihood ratio.<BR>Conclusions: The performance of the E-plate anti-H pylori IgG antibody test was comparable to that of the stool antigen test and is therefore suitable for epidemiologic studies of H pylori infection in large samples.
著者
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Fukuda Yoshihiro
Department Of Clinical Nutrition And Health Science Hyogo College Of Medicine
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Kikuchi Shogo
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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Lin Yingsong
Department Of Public Health Aichi Medical University School Of Medicine
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Nishiyama Takeshi
Department Of Information And Biological Sciences Graduate School Of Natural Sciences Nagoya City University
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UEDA Junko
Department of Astronomy, Graduate School of Science, The University of Tokyo
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Okuda Masumi
Department of General Medicine and Community Health Science, Hyogo College of Medicine
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