平滑筋収縮に伴う胸大動脈壁変形の周方向不均質性のマルチスコープ解析(S02-4 生体組織のマルチスコープメカニクス(4).ミクロとマクロ両面からのアプローチ,S02 生体組織のマルチスコープメカニクス)

概要

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We have investigated the circumferential heterogeneity of the smooth muscle (SM) contraction in this artery wall from two viewpoints. From a macroscopic viewpoint, we measured the deformation of the artery wall following SM contraction in four circumferential positions to find that the ventral section contracted more than the dorsal (P<0.005). From a microscopic viewpoint, the SM cells were isolated from the ventral and the dorsal regions by enzymatic digestion to compare the contractility of the cells obtained from the different circumferential positions. All cells isolated from the ventral side become shorter than 40μm upon contraction, while about 8% of the cells obtained from the dorsal side remained elongated even after the stimulation with 10^<-5>M norepinephrine. These results may indicate that 1) the population of the smooth muscle cells is heterogeneous; 2) less contractile cells reside in the dorsal side of the aortic wall, causing the circumferential heterogeneity, in the contraction.
一般社団法人日本機械学会の論文
2004-09-04