Preferential Sensitization of Tumor Cells to Radiation by Heat Shock Protein 90 Inhibitor Geldanamycin

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概要

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• The purpose of this study was to investigate the radiosensitizing effect of geldanamycin (GA), an inhibitor of heat shock protein 90, on tumour cells and normal cells. We tested the effect of a combination of GA and radiation on cell survival, PI3K/Akt-related proteins and apoptosis induction. GA sensitized tumour cells to radiation in preference to normal cells. In addition, a combination of radiation and GA abolished Akt activities and strongly enhanced the induction of apoptosis in tumour cells which depend on Akt protein activities for cell survival. The present data support the hypothesis that GA sensitizes tumour cells by modulating the balance among mitogenic, antiproliferative and apoptotic pathways. Targeting Hsp90 in tumour cells may lead to the development of new radiosensitizing strategies in radiotherapy.

• 日本放射線影響学会の論文
• 2005-06-30

著者

• Kubata Nobuo

  Ibaraki Prefectural Univ. Of Health Sci.

• Kubota Nobuo

  Pola Chemical Industries Inc.

• Kubota Nobuo

  Department Of Radiological Sciences Ibaraki Prefectural University Of Health Sciences

• Kubota Nobuo

  Department Of Radiological Sciences. Ibaraki Prefectural University Of Health Sciences

• MATSUMOTO Yoshitaka

  Department of Radiological Sciences. Ibaraki Prefectural University of Health Sciences

• MACHIDA Hikaru

  Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences

• Machida Hikaru

  Department Of Radiological Sciences Ibaraki Prefectural University Of Health Sciences

• Kubota Nobuo

  Department Of Pharmacology School Of Medicine Showa University

• Matsumoto Yoshitaka

  Heavy-ion Radiobiology Res. Group National Inst. Of Radiological Sciences

• Matsumoto Yoshitaka

  Department Of Radiological Sciences. Ibaraki Prefectural University Of Health Sciences:(present Addr

• Matsumoto Yoshitaka

  Department Of Chemistry And Materials Technology Kyoto Institute Of Technology

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