生物学的視点に基づくオブジェクト指向生体機能シミュレーション(<特集>ライフサイエンス)

概要

論文の詳細を見る
Quantitative explanation of various cell functions is still difficult, although there is a huge amount of accumulation of knowledge about the biology and physiology on both the molecular and cellular levels. Therefore, the quantitative dynamic computer model, which integrates the biological functions, may provide a powerful tool to create and test hypotheses. In this study, the object-oriented method was applied to develop the computational model of the cell function. The cardiac cell model, which is described by a set of ordinary differential equations, was separated into the functional modules such as ion channels and the variables such as ion concentrations. The functional modules were independent from each other and classified according to the biological bases. The interaction of the functional modules and the variables are represented in the graph. The development of the lager scale models composed of individual functional modules will facilitate developing a large variety of biological models.
日本シミュレーション学会の論文
2004-03-15