有機溶剤代謝産物の尿中排泄に及ぼす肉体負荷の影響 : 第1報肉体負荷による尿中馬尿酸およびグリシン排泄からみたグリシン抱合能の変動

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Effects of physical loads on the excretion of urinary glycine conjugates, which are commonly used as an index of organic solvent intake, were examined. After physical exertion by Kendo exercise in university students for about 2 hours, urinary protein excretion changed from the levels of (-) or (+) before the exercise to (+) or (〓) after the exercise revealed by the test-tape semi-quantitative indication, and the levels of urinary creatinine increased to approximately 1.9 time the initial level. Under the present experimental conditions, the following results were obtained. 1) Statistically no significant change was observed in the levels of urinary hippuric acid, but an increasing trend was recognized. 2) The glycine levels in the urine decreased and the significance was stressed when the values were adjusted with reference to the specific gravity of urine or to the levels of urinary creatinine. 3) The ratio of hippuric acid to the glycine in the urine increased almost twice as high as the initial ratio and the physical load seemed to promote the glycine conjugation. 4) As to the adjusted levels of urinary metabolites, especially due to several organic solvents, values adjusted with reference to the specific gravity of urine and those to the levels of urinary creatinine correlated well in the samples collected before the exertion. But a poor correlation was observed in the samples collected after the exertion. Therefore, a notice should be given when the adjustment of the values with reference to the levels of urinary creatinine, which is widely used in the health administration practice for organic solvent workers to assess the levels of exposure, since the adjusted values were lowered unnecessarily by excess excretion of creatinine after the physical exertion and the tendency would be exaggerated especially under the low level exposure to organic solvent vapours in the work yard.
社団法人日本産業衛生学会の論文
1982-07-20

有機溶剤代謝産物の尿中排泄に及ぼす肉体負荷の影響 : 第1報肉体負荷による尿中馬尿酸およびグリシン排泄からみたグリシン抱合能の変動

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有機溶剤代謝産物の尿中排泄に及ぼす肉体負荷の影響 : 第1報 肉体負荷による尿中馬尿酸およびグリシン排泄からみたグリシン抱合能の変動

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有機溶剤代謝産物の尿中排泄に及ぼす肉体負荷の影響 : 第1報肉体負荷による尿中馬尿酸およびグリシン排泄からみたグリシン抱合能の変動