四塩化炭素および四塩化エタンの急性毒性に関する実験的研究 : クロル炭化水素の肝障害性第3報

概要

論文の詳細を見る
Carbon tetrachloride and 1,1, 2,2-tetrachloroethane have a specific hepatotoxicity and belong to the most toxic agents among chlorinated hydrocarbons. The threshold limit value (TLV) of carbon tetrachloride by ACGIH is 10 ppm, and that of 1,1,2,2-tetrachloroethane is 5 ppm. Therefore, it has been evaluated that the toxicity of carbon tetrachloride is lower than that of 1,1,2,2-tetrachloroethane in the field of industrial hygiene. In order to examine the validity of this evaluation, the authors made Cb female mice weighing 20-23 g inhale the above vapors at 800 ppm for 3 hours separately, and attempted to compare the acute toxicity of carbon tetrachloride with that of 1,1,2,2-tetrachloroethane, observing the course of the changes of lipid contents in the liver and plasma and the damage of liver microsomes after the exposure. The results obtained are summarized as follows: 1. The changes of hepatic triglyceride and phospholipid levels by the exposure to carbon tetrachloride were almost similer to those of 1,1,2,2-tetrachloroethane. 2. The decreasing rate of plasma triglyceride and phospholipid contents by the exposure to carbon tetrachloride was significantly higher than those of 1,1,2,2-tetrachloroethane. 3. The damage of liver microsomes was recognized in the exposures to both carbon tetrachloride and 1,1,2,2-tetrachloroethane. As whole, it is concluded that the hepatotoxicity of carbon tetrachloride is almost the same as that of 1,1,2,2-tetrachloroethane, or the former is a little higher than the latter.
社団法人日本産業衛生学会の論文
1971-02-20

四塩化炭素および四塩化エタンの急性毒性に関する実験的研究 : クロル炭化水素の肝障害性第3報

スポンサーリンク

概要

著者

関連論文

スポンサーリンク

四塩化炭素および四塩化エタンの急性毒性に関する実験的研究 : クロル炭化水素の肝障害性 第3報

スポンサーリンク

概要

著者

関連論文

スポンサーリンク

四塩化炭素および四塩化エタンの急性毒性に関する実験的研究 : クロル炭化水素の肝障害性第3報