赤血球内水分量におよぼす鉛の影響 : 第1報 in vitroの実験

概要

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We observed in vitro experiment that lead increased osmotic resistance of normal human erythrocytes and decreased mean corpuscular volume and intracellular potassium. Though the mechanism of the increased osmotic resistance of erythrocytes caused by lead has not yet been completely clarified, the following hypothesis could be accepted. Lead cause leakage of water from erythrocytes, which means that more water can enter the cell before hemolysis occurs. But, there has been no report of direct measurement of the intracellular water content of of erythrocytes treated with lead. This paper tried to clarify the relationship between intracellular water and osmotic resistance of lead treated erythrocytes in vitro experiment. The results were: 0.05 μmol/ml of lead increases osmotic resistance, trapped water content and plasma water content of normal human blood and decreases intracellular water content after incubation for 2 hours at 37℃.
社団法人日本産業衛生学会の論文
1981-05-20