薬剤の水溶液中での安定性に関する研究(第1報) : 2,2-ジフェニル-2-ブロバルギルオキシ酢酸ジメチルアミノエチルエステル塩酸塩の水溶液中での反応速度論的研究

概要

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2,2-Diphenyl-2-propargyloxyacetic acid (2-dimethylaminoethyl) ester hydrochloride (DPDM) is decomposed in aqueous solution. It was confirmed by thin-layer chromatography and gas chromatography that the decomposition of DPDM occurs as consecutive reactions. In the first step, DPDM is hydrolysed to propargyloxy-benzilic acid (BPE) and β-dimethylaminoethanol hydrochloride and next, BPE is decomposed to benzilic acid (BA) and propargyl alcohol. As BPE is extremely slightly soluble in water, BPE precipitates in aqueous solution in proportion to decomposition of DPDM. In the present investigation, the hydrolytic decomposition of DPDM and BPE was studied in order to obtain more stable aqueous preparations, and DPDM was found to be stable at pH 2.5 to 3.5. Variations in the concentration of DPDM, BPE, and BA in aqueous solution were calculated by an analog computer. Data observed in the experiment corresponded with those calculated by the computer.
公益社団法人日本薬学会の論文
1968-11-25