ビタミンAの安定性にかんする研究 : (IV) 水・エタノール系におけるレトロビタミンAアセテートの分解速度

概要

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In the previous studies of this series, it was investigated the influence of water content on the change of vitamin A acetate and anhydrovitamin A in aqueous ethanolic solution. This report describes the results of a similar study on the stability of retrovitamin A acetate, an intermediate product of vitamin A acetate in aqueous ethanolic solution. Retrovitamin A acetate was determined by spectrometric method (367mμ in ethanol). The amount of changed products of retrovitamin A acetate was examined by alumina column chromatography and thin layer chromatography. The stability of retrovitamin A acetate in 60-100% ethanolic solution, at 35 and 50℃ decreased gradually as water increased. Three substances were recognized as changed products of retrovitamin A acetate. (a) Retrovitamin A alcohol (Rf 0.29) , (b) unknown substance which seems to be the same substance of changed anhydrovitamin A, having maximum absorbance at 283 mμ (Rf 0.16) , (c) unknown substance (Rf 0.11). Anhydrovitamin A and unknown substances I, II. which were reported previously as the changed products of vitamin A acetate were not recognized. The reversible reaction of retrovitamin A acetate to vitamin A acetate or its alcohol was not observed.
日本ビタミン学会の論文
1969-11-25