金属蛋白質の研究(第9報) : 亜鉛過剰投与による血清銅およびセルロプラスミン活性に対する影響

概要

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Excess dietary zinc resulted in the lowered growth, hemoglobin concentration, and ceruloplasmin activity, with significant decrease in the concentration of serum copper. The addition of 0.2% copper to the diet containing 1.0% zinc was effective in preventing anemia and decrease in ceruloplasmin activity. Administration of a large amount of copper alone caused an increase in serum copper and a marked increase in ceruloplasmin activity (Table I and II). The animals receiving excess dietary zinc developed a mild anemia and showed a significant decrease in ceruloplasmin activity, When copper-histidine chelate was administered intraperitoneally to the animals, the decrease in ceruloplasmin activity recovered, but the concentration of hemoglobin was little affected (Fig. 1). These results suggested that the excess dietary zinc induced a copper-deficient state, and an antagonistic correlation existed between zinc and copper.
公益社団法人日本薬学会の論文
1966-06-25