Radioisotopic Studies on Percutaneous Absorption. I. Absorption of Water-soluble Substances from Hydrophilic and Absorption Ointments through Mouse Skin.

概要

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The percutaneous absorbability of water-soluble substances from emulsion-type ointments was demonstrated by measuring the absorption of radioactivity after application of hydrophilic and absorption ointments containing Na^<131>I, ^<59>Fe-EDTA, ^<59>Fe-tiron or ^<22>NaCl to hairclipped mouse skin. The absorption of lipid-soluble ^<59>Fe-cupferron and ^<59>Fe-carbamate from these vehicles was quite small. The large promoting effect of polyethylene oleyl ether on the percutaneous absorption of ^<59>Fe-EDTA from polyethylene glycol 1500 through mouse skin suggested some important contribution of surface-active agents to the percutaneous absorption of water-soluble substances from hydrophilic and absorption ointments.
公益社団法人日本薬学会の論文
1967-10-25