Radioisotopic Studies on Percutaneous Absorption. II. Comparison of the Rate of Absorption through Mouse Skin of Several Water-soluble Substances from Emulsion-type Ointments

概要

論文の詳細を見る
In a comparison of the percutaneous absorption of ^<22>Na+ with that of ^<36>Cl-, zinc-EDTA-^<65>Zn, ferric-EDTA-^<59>Fe, ferric-tiron-^<59>Fe or ferric-chromotropic acid-^<59>Fe by the"double isotopic method, "it was demonstrated that water-soluble substances added simultaneously to absorption or hydrophilic ointment were absorbed at widely different rates through hair-clipped mouse skin. These results suggest that water-soluble substances added to an emulsion-type ointment may be absorbed through the skin into the body not as emulsified particles themselves but as solution or particles ultimately free of ointment base. It was also demonstrated that percutaneous absorbability of ferric-chromotropic acid-^<59>Fe was significantly lower than that of ferric-tiron-^<59>Fe when a comparison of the rates of absorption of these two radioactive compounds was made indirectly by using the absorption rate of ^<22>Na+ added simutlaneously with each ^<59>Fe-chelate compound to the absorption ointment as a standard. Thus, it was inferred that, when other conditions are similar, the percutaneous absorbability of water-soluble substances from emulsion-type ointment through mouse skin may be decreased with an increase in molecular size.
公益社団法人日本薬学会の論文
1973-06-25