Bile Acid Composition in the Fistula Bile from Fasted, Cholesterol-Fed or Thyroid Powder-Fed Rats

概要

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TLC-analysis for bile acid composition was carried out on the bile samples obtained by bile duct-cannulation from the rats fasted for 48 hr and from those kept continuously on a diet supplemented with 1% cholesterol or 2% thyroid powder. The secretion of total taurine-conjugated bile acids decreased after fasting, only except the secretion of taurodeoxycholic acid which was maintained at normal level. The fasted group, thus, demonstrated an increase in the ratio of trihydroxy to dihydroxy bile acids and a decrease in another ratio of bile acid components, (taurocholic acid+taurodeoxycholic acid)/(taurochenodeoxycholic acid+tauromuricholic acid+taurohyodeoxycholic acid), as compared with the normal group. Cholesterol-feeding increased slightly the biliary output of total bile acids. However, both of the above ratios for this group were nearly the same to those for the normal group. On the other hand, thyroid powder-feeding caused an increase of taurocholic acid accompanied by a concomitant decrease of taurodihydroxy bile acids within the normal range of total bile acid secretion, resulting in increases of both the ratios over the normal levels. In all the experimental groups including the normal, the incorporation of intravenously injected taurine-^<35>S into biliary taurocholic, tauromuricholic and taurodihydroxy bile acids was approximately proportional to the secreted amounts of these fractions.
公益社団法人日本薬学会の論文
1974-01-25