水溶液およびアルコール溶液におけるビタミンK_5のポーラログラフ的挙動とビタミンK_5の定量への応用

概要

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The electrode reaction of vitamin K_5 (4-amino-2-methyl-1-naphthol hydrochloride) on a mercury electrode was studied by polarography in aqueous and alcoholic solutions. Vitamin K_5 shows two well-defined anodic waves on a direct current (DC) polarogram obtained from both aqueous and acidic ethanol solutions. One of them is due to the oxidation of 4-amino-2-methyl-1-naphthol (I) and its limiting current was found to be proportional to the vitamin K_5 concentration, and the other corresponds to the formation of mercurous chloride on the electrode surface. Electro-oxidation of I also gives rise to a distinct peak on an alternating current (AC) polarogram obtained from aqueous solution, whose height is proportional to the amount of vitamin K_5 in a very low concentration range. Such experimental results have been confirmed to be advantageously applicable to the microdetermination of vitamin K_5. The AC polarographic method can be applied to determine a minute quantity of vitamin K_5 as low as 0.1 ppm range. The simultaneous determination of vitamin K_5 and other vitamin K's can be made by the measurement of DC polarogram in acidic ethanol solution with satisfactory results.
公益社団法人日本薬学会の論文
1976-06-25