アミノアルコール誘導体の研究(第5報)N-(3-ジアルキルアミノ-2-ハイドロキシプロピル)-4-フェニルピペリジン・ジハイドロクロライドの抗炎症作用

概要

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In order to develope a non-steroidal anti-inflammatory drug, N-(3-dialkylamino-2-hydroxypropyl)-4-phenylpiperidine・2HCl was synthesized. Five compounds were examined for anti-inflammatory effects on swelling of rat hind paw induced by dextran and on mice scald oedema, diuresis effects, depression effects of normal body temperature. In general, the order of anti-inflammatory effects of these compounds was IIIe>IIId>IIIb>IIIc>IIIa. The inhibition percentage of scald oedema of compound No. IIId, e were higher than that of cortisone acetate and aspirin. These compounds had scarcely diuresis action. The order of depression effects on normal body temperature was IIIc>aminopyrine>IIIe≒IIId>IIIb>IIIa.
公益社団法人日本薬学会の論文
1980-12-25