アミノアルコール誘導体の研究(第2報)1-ジアルキルアミノ-3-置換-2-プロパノール誘導体の合成および薬理作用

概要

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In order to investigate the relation between clemical structure and pharmacological activities, 1-dialkylamino-2-propanol derivatives and their related compounds were synthesized. These compounds were examined in rabbit and mouse for local anesthetic activity, anti-spasmodic activity, ana1gesic activity on pain produced by a hot plate and inhibitory action on writhing syndrome produced by acetic acid. Several substances had stronger analgesic action that pyrabita1 and almost all the compounds were proved to have antispasmodic aitivity at the concentration from 10^<-5> to 10^<-6> g/ml. 1-Diisobutylamino-3-piperidino-2-propanol dihydrochloride (IIIf), 1-dibutylamino-3-butoxy-2-propapol hydrochloride (IVf), 1-dibutyl-amino-3-hexylthio-2-propanol hydrochloride (Vk), and 1-dibutylamino-2-(β-cyanoethoxy)-3-diethylaminopropane dihydrochloride (VIIId) showed a stronger local anesthetic activity than cocaine or lidocaine.
公益社団法人日本薬学会の論文
1974-01-25