生薬修治の化学的解明(第4報)附子(Aconiti Tuber)その3 : 高速液体クロマトグラフィーによる附子中のアコニチン型アルカロイドの定量

概要

論文の詳細を見る
As a continuing study on the chemical characterization of the processing of "fuzi", a quantitative method by high performance liquid chromatography (HPLC) for aconitine alkaloids : aconitine (1), hypaconitine (2), mesaconitine (3), lipoaconitine (4), lipohypaconitine (5), lipomesaconitine (6), lipodeoxyaconitine (7), benzoylaconine (1a), benzoylhypaconine (2a), and benzoylmesaconine (3a), has been developed. By the use of this HPLC method, aconitine alkaloid contents in 15 kinds of "fuzi"(processed and unprocessed, originated in Japan and China) were examined. It was found that 13 out of 15 kinds of "fuzi"contained lipo-alkaloids (4,5,6) as major alkaloids and the contents of fatally toxic alkaloids such as 1,2,and 3 decreased in processed "fuzi"(e.g."pao-fuzi") whereas the contents of lipo-alkaloids increased.
公益社団法人日本薬学会の論文
1984-08-25