トリテルペノイドサポゲニンを用いる液・固クロマトグラフィーにおける強成分溶媒の相対強度の図式化

概要

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To optimize a solvent system systematically for liquid-solid chromatography separation, the strength indices of stronger solvents such as diethyl ether (B_1), ethyl acetate (B_2), acetone (B_3), tetrahydrofuran (B_4), dioxan (B_5) and 2-propanol (AB) were determined on the basis of a linear relationship between the logarithm of the capacity ratios and the logarithm of the solvent composition in binary systems containing n-hexane (O) as a diluent. A new procedure for the graphic schematization of the relative strength and equi-eluotropic composition of stronger solvents is elaborated. The experimental results obtained with triterpenoid sapogenins were compared with the Snyder's solvent strength parameter and the Neher's calculation for predicting the equi-eluotropic solvent composition and the differences among three strength parameters are discussed.
公益社団法人日本薬学会の論文
1983-02-25