ジギタリス配糖体のシリカゲル液体クロマトグラフィーにおける溶媒系の設計.製剤中のジゴキシンの定量

概要

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Solvent system optimization for digitalis glycosides was examined by silica gel normalphase liquid chromatography. 2-Propanol was added to a diluent, n-hexane, for increasing the solubility of water which was found to be a fine modifier for reducing peak tailing. In addition, ethanol was incorporated into the carrier solvent as a strong component to control the retentivity. As a systematically designed four component phase system, n-hexane-2-propanol-ethanol-water (52 : 20 : 25 : 3 v/v) was applied to the high performance liquid chromatographic analysis of digoxin in commercially available tablet preparations, using the clean-up procedure. The phase system reported here showed preferable selectivity for the simultaneous resolution of three digitalis glycosides.
公益社団法人日本薬学会の論文
1984-05-25