Clinical Application of Basic Arginine Amidase in Human Male Urine

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概要

• 論文の詳細を見る

• Basic human urinary arginine amidase (or esterase, called BHUAE) which is only found in male urine, was measured from normal volunteers between the age of 4 and 70 years using D-valyl-L-leucyl-L-arginine-p-nitroanilide as a substrate. BHUAE increases during early adolescence, between 8 to 17 years of age. Then, BHUAE decreases in the twenties and takes a certain range of value in the mature age group, between the late thirties and fifties.In patients with prostate cancer, a significant increase in BHUAE was demonstrated in comparison with the healthy male group (control) over 55 years old. On the other hand, patients with benign prostatic hypertrophy showed no significant elevation of this enzyme activity. It would appear that the measurement of BHUAE in urine can be used as a marker of prostate cancer in an advanced age group.

• 公益社団法人日本薬学会の論文
• 1996-08-15

著者

• UMEDA Takashi

  Department of Clinical Acupuncture, Kansai College of Oriental Medicine

• Umeda Takashi

  Department Of Urology Teikyo University School Of Medicine

• Umeda Takashi

  Department Of Acupuncture And Moxibustion Kansai University Of Health Sciences

• FUJIMOTO Yukio

  Department of Naval Architecture, Ocean Engineering and Engineering Systems, Hiroshima University

• MATSUDA Yoshifumi

  Department of Biochemistry, Meiji College of Pharmacy

• MIYASHITA Atushi

  Department of Urology, Sanraku Hospital

• AKIHAMA Sumiyuki

  Department of Biochemistry, Meiji College of Pharmacy

• Miyashita Atushi

  Department Of Urology Sanraku Hospital

• Akihama Sumiyuki

  Department Of Biochemistry Meiji College Of Pharmacy

• Matsuda Yoshifumi

  Department Of Biochemistry Meiji College Of Pharmacy

• Fujimoto Yukio

  Department Of Clinical Biochemistry Hokkaido Institute Of Pharmaceutical Sciences

• Fujimoto Yukio

  Department Of Biochemistry Hokkaido Institute Of Pharmaceutical Sciences

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