SOME PROPERTIES OF THE CRUDE EXTRACT OF SCORPION TELSONS' FROM HETEROMETRUS GRAVIMANUS AND PRESENCE OF ACETYLCHOLINE- AND HISTAMINE-LIKE SUBSTANCES
スポンサーリンク
概要
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The lyophilized crude scorpion venom from Heterometrus gravimanus was administered to anesthetized cats, and the changes in electrocardiogram, hypotensive effect, increase in the depth of respiration and blood flow were observed. From the pharmacological experiment on isolated guinea pig ileums, the presence of both acetylcholine-and histamine-like substances was suggested in the crude venom. Acetylcholine-like substance was compared with an authentic acetylcholine on the silicagel thin-layer chromatography, and the amount was estimated to be 8-15 μg equivalent to acetylcholine per mg venom by the Magnus method. Histamine-like substance was extracted and purified from the crude venom, and was run on both silicagel and polyamide thin-layer chromatographies concurrently with an authentic histamine and 5-hydroxytryptamine. By both bioassay with isolated guinea pig ileum and chemical determination with the fluorometric methods, the content of histamine-like substance was calculated to be about 30 μg equivalent to histamine per mg venom. 5-Hydroxytryptamine was not found. Hemolytic action was observed in the human erythrocytes with the venom and the maximal action was found at pH 5.5.
- 公益社団法人日本薬学会の論文
著者
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FUJIMOTO Yukio
Department of Naval Architecture, Ocean Engineering and Engineering Systems, Hiroshima University
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Fujimoto Yukio
Hokkaido Institute Of Pharmaceutical Sciences:hokkaido Institute Of Pharmaceutical Sciences
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Fujino Sumiko
Hokkaido Institute Of Pharmaceutical Sciences
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Fujino Sumiko
Department Of Pharmacology Hokkaido Institute Of Pharmaceutical Sciences:department Of Pharmacology
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KAKU TENMIN
(Present address)Yamanouchi Pharmaceutical Co, Ltd.
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Fujimoto Yukio
Department Of Biochemistry Hokkaido Institute Of Pharmaceutical Sciences
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Kaku Tenmin
(present Address)yamanouchi Pharmaceutical Co Ltd.
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