STUDIES ON THE INDONESIAN ANTIARIS TOXICARIA SAP
スポンサーリンク
概要
- 論文の詳細を見る
The present research is on a milky sap obtained from the Antiaris toxicaria tree (Moraceae) which is called Upas or Ipoh in Indonesia. The crude sap was administered to anesthetized rats, and changes in electrocardiogram (ECG) and systemic blood pressure were observed. Biologically and pharmacologically active components were extracted from the crude sap by means of water-acetone solution. Based on the strength of chemical qualitative detection tests of the sap extract (SE), cardiac glycosides are supposed to be the main components. The SE inhibited the Na^+-, K^+-ATPase (EC 3.6.1.3) which was partially purified from guinea pig heart muscle. When the SE and, concurrently, authentic ouabain were applied to isolated frog heart muscles, the fall of twitch tension was observed after the increased tension on mechanograms. These facts suggest that the main components of the milky sap are cardiac glycosides, and the glycosides affect Na^+-, K^+-ATPase activity of muscle membrane and heart muscle contraction.
- 公益社団法人日本薬学会の論文
著者
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HOSHI KATSUJI
Hokkaido Institute of Pharmaceutical Sciences
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Fujimoto Yukio
Hokkaido Institute Of Pharmaceutical Sciences:hokkaido Institute Of Pharmaceutical Sciences
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Fujino Sumiko
Hokkaido Institute Of Pharmaceutical Sciences
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SUZUKI YUKO
Hokkaido Institute of Pharmaceutical Sciences
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KANAIWA TAKAO
Hokkaido Institute of Pharmaceutical Sciences
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AMIYA TAKASHI
Hokkaido Institute of Pharmaceutical Sciences
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Suzuki Yuko
Hokkaido Institute Of Pharmaceutical Sciences:(present Address) Department Of Pharmacology Sapporo M
関連論文
- PERTURBATION OF HEPATIC GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- STUDIES ON THE INDONESIAN ANTIARIS TOXICARIA SAP
- SOME PROPERTIES OF THE CRUDE EXTRACT OF SCORPION TELSONS' FROM HETEROMETRUS GRAVIMANUS AND PRESENCE OF ACETYLCHOLINE- AND HISTAMINE-LIKE SUBSTANCES
- The structure of nitronitrosoaconitinic acid, the oxidation product of aconitine with nitric acid.
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