Effect of Chondroitinase on Dermatan Sulfate-Facilitated Arginine Amidase Released from Rabbit Ear Artery
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概要
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We examined the effects of chondroitinases on the release of dermatan sulfate (DS)-induced arginine amidase (AA) from rabbit ear artery. DS-induced AA release was significantly decreased by treatment with chondroitinase ABC (ABCase) in the rabbit ear artery. On the other hand, Chondroitinase ACII (ACIIase) enhanced spontaneous and DS-induced AA release. Heat-inactivated ABCase and ACIIase did not affect spontaneous and DS-induced AA release. Furthermore, ABCase, but not ACIIase and heat-inactivated chondroitinases, degraded DS. These results indicate that the facilitatory effect of DS-induced AA release from the rabbit ear artery is affected by the molecular size of DS.
著者
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MIYAZAKI Kyosuke
Seikagaku Corporation
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Ishii-nozawa Reiko
Department Of Clinical Pharmacology Meiji Pharmaceutical University
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Takeuchi Koichi
Department Of Anatomy
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Mita Mitsuo
Department Of Molecular Pharmacology Meiji College Of Pharmacy
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Matsuda Yoshifumi
Department Of Biochemistry Meiji College Of Pharmacy
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Miyazaki Kyosuke
Seikagaku Kogyo Co.
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Naito Tatsuya
Department of Clinical Pharmacology, Meiji Pharmaceutical University
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Matsuda Yoshifumi
Department of Functional Bioanalysis, Meiji Pharmaceutical University
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