Dysfunction of Neurotransmitter Modulation System on Adrenergic Nerves of Caudal Artery in Type 2 Diabetic Goto–Kakizaki Rats

スポンサーリンク

概要

• 論文の詳細を見る

• The Goto–Kakizaki (GK) rat is a non-obese and spontaneous model of mild Type 2 diabetes mellitus. In the present study, we compared the regulatory mechanisms of endogenous norepinephrine (NE) release from sympathetic nerves of caudal arteries of 12-week-old GK rats and age-matched normal Wistar rats. Electrical stimulation (ES) evoked significant NE release from caudal arteries of Wistar and GK rats. The amounts of NE released by ES were almost equal in Wistar and GK rats, although the NE content in caudal artery of GK rats was significantly lower than that of Wistar rats. We examined the effects of an α2-adrenoceptor agonist, clonidine (CLO), and an α2-adrenoceptor antagonist, yohimbine (YOH), on the release of endogenous NE evoked by ES. CLO significantly reduced NE release from caudal arteries of Wistar but not GK rats. On the other hand, YOH significantly increased NE release from both rats. Furthermore, we examined the effects of an A1-adenosine receptor agonist, 2-chloroadenosine (2CA), and an A1-adenosine receptor antagonist, 8-sulfophenyltheophylline (8SPT), on the release of endogenous NE evoked by ES. 2CA significantly reduced NE release from caudal arteries of Wistar but not GK rats. On the other hand, 8SPT did not affect NE release from both rats. These results suggest that the dysfunction of negative feedback regulation of NE release via presynaptic receptors on sympathetic nerves in GK rats may be involved in the autonomic nervous system dysfunction associated with diabetic autonomic neuropathy.

著者

• Shoji Masaru

  Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine

• Ishii-nozawa Reiko

  Department Of Clinical Pharmacology Meiji Pharmaceutical University

• Takeuchi Koichi

  Department Of Anatomy

• MITA Mitsuo

  Department of Pharmacodynamics, Meiji Pharmaceutical University

• Mita Mitsuo

  Department Of Molecular Pharmacology Meiji College Of Pharmacy

• Ishii-Nozawa Reiko

  Department of Clinical Pharmacology, Meiji Pharmaceutical University

関連論文

• Glucocorticoidal Regulation of Pituitary Vasopressin Content in Rats
• PJ-379 Intracellular Signaling Pathways for an Anti-apoptotic Effect of Endothelin-1 in Cardiomyocytes(Apoptosis/Necrosis/Regeneration 1 (M) : PJ63)(Poster Session (Japanese))
• V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation
• Effects of Dermatan and Dextran Sulfates on Arginine Amidase Activity Released from Isolated Rabbit Arteries
• OJ-196 AAV-mediated IL-10-gene Transfer into Apolipoprotein E-deficient Mice Inhibits Atherosclerosis through Anti-inflammatory and Cholesterol-lowering Effects(Atherosclerosis, Basic 2 (IHD) : OJ22)(Oral Presentation (Japanese))
• Involvement of c-Src-Bcl-xL Pathway in Anti-apoptotic Effects of Endothelin in Rat Cultured Cardiac Myocytes
• Interleukin-10 Prevents Atherogenesis through Inhibition of MCP-1 Expression and Correction of Lipoprotein Metabolism in Apo E-Deficient Mice
• Efficient Transduction of Primate Embryonic Stem Cell-Derived Cardiomyocytes Using a Simian Immunodeficiency Virus Vector
• Lack of Association between Y Chromosome Alu Insertion Polymorphism and Hypertension
• Analysis of Aldehyde Dehydrogenase 2 Gene Polymorphism and Ethanol Patch Test as a Screening Method for Alcohol Sensitivity
• Two Non-steroidal Anti-inflammatory Drugs, Niflumic Acid and Diclofenac, Inhibit the Human Glutamate Transporter EAAT1 Through Different Mechanisms
• Augmentation of α_1-Adrenoceptor-Mediated Contraction by Warming Without Increased Phosphorylation of Myosin in Rat Caudal Arterial Smooth Muscle
• Collection of Medical Drug Information in Pharmacies : Drug Event Monitoring (DEM) in Japan
• Effect of Dextran Derivatives on Arginine Amidase Activities Released from Isolated Rabbit Arteries
• ALL-OR-NONE RESPONSE OF ISOLATED SMOOTH MUSCLE CELLS TO ACETYLCHOLINE
• The Affinity of Histamine for Gq Protein-Coupled Histamine H1-Receptors Is Predominantly Regulated by Their Internalization in Human Astrocytoma Cells
• Effect of Chondroitinase on Dermatan Sulfate-Facilitated Arginine Amidase Released from Rabbit Ear Artery
• Dysfunction of Neurotransmitter Modulation System on Adrenergic Nerves of Caudal Artery in Type 2 Diabetic Goto–Kakizaki Rats
• The Affinity of Histamine for Gq Protein-Coupled Histamine H_1-Receptors Is Predominantly Regulated by Their Internalization in Human Astrocytoma Cells
• Detection of Arginine Amidases Released from Isolated Rabbit Arteries
• Niflumic Acid Activates Additional Currents of the Human Glial L-Glutamate Transporter EAAT1 in a Substrate-Dependent Manner

もっと見る 閉じる

スポンサーリンク